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Addition of a carbohydrate known as sialic acid to IgG antibodies

Addition of a carbohydrate known as sialic acid to IgG antibodies

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R and R' represent connecting sugar monomers of the polysaccharide. Red asterisks indicate sites of diol cleavage. Sialic acid is also called ...

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Sialidase enzyme activity reflects microbiological status. BV status was assessed by Nugent scoring of Gram

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Impact of Asn297-linked glycan tree on FcγR-mediated effector functions of IgG. The composition of the IgG glycan tree linked to the conserved amino acid ...

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Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins | Nature

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Differential effect of bacterial and viral sialidases in sialic acid hydrolysis, as determined by fluorometric

FIGURE 1

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BV sialidases act on sialic acids presented in multiple contexts relevant to the reproductive mucosa.

2 Schematic representation of sialic acid biosynthesis pathway in mammalian cells

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Overview of different glycosylation assays. PNGase F: peptide -N-Glycosidase F, · Levels of sialic acid ...

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The conserved N-linked carbohydrate domain of IgG is attached to Asn-297 of

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Biosynthetic pathway of physiological and engineered sialic acid.

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At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody | Scientific Reports

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Complement dependent cytolysis of lymphoblasts by purified antibody directed against O-

Figure 2: N-linked glycosylation types

FIGURE 2

Removal of ␣ 2– 6-linked sialic acid on secretory component and heavy chain

Importance of Controlling N-Linked Glycans on Therapeutic Monoclonal Antibodies

N-glycans which showed increased relative abundance in cancer patient serum compared with normal volunteer.

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Spatial arrangement of sialic acid residues on an N-linked glycoprotein. A typical oligosaccharide, which includes a conserved pentasaccharide core, ...

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15 N- (A-C) and 13 C- (D, E) HSQC

( A ) COSY, ( B ) TOCSY and ( C ) HSQC spectra,

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Chromatograms representing the sialic acid content of neuraminidase treated gp96. Each of the chromatograms is

... coated on microtiter plates and incubated with various synthetic SGCs or oligosaccharides (1 μg/mL, X-axis), including N-acetylneuraminic acid (Neu5Ac), ...

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IgG Glycoforms and their inflammatory properties. Ig heavy chain residue CH2-84.4 is post-translationally modified with the addition of an N-glycan, ...

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Quantification of gp96 sialic acid from rat and human purified tumor tissues. The sialic acid

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins | Nature

Levels of sialic acid, fucose, and galactose in infused IVIG and endogenous IgG from

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Fc γ R cross-linking by immunoglobulin (IgG

Carbohydrate microarray analysis of siglec E-Fc. A , binding of siglec E-

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Graphical Abstract

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Optimization of sialylation process leads to a sialylated Fc with symmetrical A2F/A2F Fc glycoforms

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Fig. 1

Structure of IgG and IgY.

Controlling Glycosylation in Fusion Protein Manufacturing to Generate Potent Biobetters

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Identification of sialic acid derivatives after H185 antigen immunoprecipitation. The H185 antigen, which in

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis | Nature Communications

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Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis | Nature Communications

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