Web Analytics Made Easy - StatCounter
Adefovir dipivoxil CAS 142340996 is a nucleotide analog

Adefovir dipivoxil CAS 142340996 is a nucleotide analog

<

FIG. 1.

Figure 1

Adverse Events Reported by at Least 5 Percent of Patients in the Adefovir Dipivoxil Group.

Figure 2. Mean Plasma HBV DNA Levels.

A scheme depicting intracellular activation, and the antiviral mechanism of action of tenofovir

Adverse Events Reported by at Least 10 Percent of Patients in the Group Given 30 mg of Adefovir Dipivoxil per Day.

Meta-analysis of the rates of nephrotoxicity with adefovir therapy for single-arm studies using the random (DerSimonian-Laird) model.

www.frontiersin.org

Download full-size image

Figure 1

LMV, lamivudine, ETV, enticavir, ADV, adefovir dipivoxil, LdT, telbivudine, LoD, lower limit of detection.

Download high-res image (609KB) ...

Download figure ...

Table 1. HBV DNA Suppression and Resistance Rates Associated with Different Therapeutic Agents.

Fig. 21

Download high-res image (292KB) ...

Table 1. Baseline Characteristics of the Study Participants.

Fig. 1

Figure 3

Fig. 1

Figure 1.

Approved anti-HBV nucleotide and nucleoside analog antivirals. The nucleosides and nucleotides approved for the treatment of chronic hepatitis B infection ...

S1 Fig. Continuous change in serum lactate concentration during 240 weeks of combined therapy.

Download high-res image (882KB) ...

Figure 2

BARACLUDE® is the tradename for entecavir, a guanosine nucleoside analogue with selective activity against HBV. The chemical name for entecavir is 2-amino-1 ...

Download full-size image

Download full-size image

b Mechanism of antiviral action of adefovir

Fig.

Figure 3. Effect of Early Viral Suppression on Treatment Outcomes.

Download full-size image

The Nucleoside Analogues Zidovudine and Didanosine are also Shown for Comparison.

Graphical abstract

Download high-res image (228KB) ...

Fig 2. Pathways for the active renal tubular excretion of antiviral drugs. Uptake of

... Hi-Res ...

Evaluation of Drug Efficacy

Viruses 09 00156 g001 550

Advantages and Disadvantages of Pegylated Interferon and Oral Nucleoside and Nucleotide Analogues as Treatment for Chronic HBV Infection.

Download full-size image

Download figure ...

Combination nucleoside analog therapy

Adefovir dipivoxil  Adenosine analogue ...

Download figure ...

Download high-res image (123KB) ...

... figure 2figure ...

Adefovir dipivoxil [Bis(pivaloyloxymethyl)ester of 9-(2-phosphonylmethoxyethyl) adenine, bis(POM)PMEA, Hepsera®].

Flow diagram. Flow diagram of the studies identified. TDF: Tenofovir disoproxil fumarate; FTC: emtricitabine; LAM: lamivudine; NA: nucleoside analogue.

Download Figure

Fig. 1

Frontiers | Cytoplasm-Translocated Ku70/80 Complex Sensing of HBV DNA Induces Hepatitis-Associated Chemokine Secretion | Immunology

The; 10. threshold ...

63.

Download high-res image (659KB) ...

Figure 1

Figure 1.

Figure 1.

Molecular structures of approved NAs.

... Download PowerPoint Slide

Recommended Approach to Monitoring and/or Managing Children with Chronic Hepatitis C Infection

Figure 2

Download full-size image

Open image in new window

Download high-res image (551KB) ...

... 38.

Fig. 1

Download high-res image (460KB) ...

HBV DNA fell below 103 copy/mL in 10 cases after 6 months (one case died due to HCC) and subsequently in one patient who switched to entecavir[95].

Figure 2. Association between survival and mutations. Comparison of postoperative (A) overall survival and (B) disease-free survival between patients with ...

Download figure ...

Drug resistant mutants of nucleos(t)ide analogues

Fig. 6

Management for patients with chronic hepatitis B virus infections.

HepG2-HS204V cells were cultured for drug assay and grown in the presence of lamivudine, adefovir, entecavir or tenofovir. Southern blot analysis of ...

Download high-res image (1MB) ...

Download full-size image

Digram showing therapeutic targets and lifecycle of hepatitis B vaccine

Figure 1

Download full-size image

Conflicts of interest

Download high-res image (301KB) ...

Download high-res image (454KB) ...

Table 3. Birth Defects, Malformations, and Adverse Events in Infants.

Fig. 6

Nucleoside and nucleotide analogues consist of a nucleobase (a purine or pyrimidine derivative) linked to a sugar moiety, and nucleotide analogues have a ...

Download full-size image

Figure 3. Inhibition of HIV-1 Infection by Entecavir at or before the Reverse-Transcription Step.

Fig. 1

Figure 1

www.frontiersin.org

Table 3. Effect of Baseline Factors and Alanine Aminotransferase Levels during Treatment on HBeAg Seroconversion Rates at Week 72.

... Hi-Res ...

Download high-res image (509KB) ...

Fusidic Acid Cream Mechanism Action

Scheme 2

Adjustment during Peg-IFN treatment for HBeAg-negative CHB patients.

Table 3: Efficacy results at 48 weeks HBeAg-negative patients11

a | Rationale underlying development of acyclic nucleoside phosphonates. Nucleoside analogues generally need to be converted by three phosphorylation steps ...