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Fig 2 drug induced mitochondrial toxicity print out to read later

Fig 2 drug induced mitochondrial toxicity print out to read later

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S1 Fig. NAC decreased mtDNA replication associated with development.

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Development of flow cytometry-based mitochondrial function assays. HL-60 cells were cultured

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Glycolysis was responsible for maintaining cell survival after mitochondrial damage. HL-60 cells were

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FIG. 2. Mitochondrial poisons depolarized MMP. HL-60 cells were cultured in RPMI-1640 (

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Colocalization of azidobupramine with the mitochondrial compartment was analyzed with two-way ANOVA with repeated measures: after 24 hours, the intensity ...

Cytotoxic compounds do not disrupt MMP. HL-60 cells were cultured in RPMI-

Figure 1. Kinetic oxygen consumption profiles of Cor.4U® cardiomyocytes are detected using the MITO-ID® Extracellular O2 Sensor Kit.

Figure 2. Measuring the effect of drug treatment on cellular oxygenation, with HepG2 3D RAFT™ structures using the MITO-ID® Intracellular O2 Sensor Probe at ...

Fig. 2. Bactericidal antibiotics induce mitochondrial dysfunction. (A) The effects of

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APAP-induced mitochondrial protein adducts and JNK activation. Mice were treated with APAP,

Possible sites of xenobiotic interference with mitochondrial function leading to mitochondrial toxicity. Adapted from:

Dose response of the cytochrome c oxidase inhibitor KCN on glutamate/malate-driven ADP

Fig. 2. Bactericidal antibiotics induce mitochondrial dysfunction. (A) The effects of

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THS caused significant changes in expression of genes associated with mitochondrial function. A, Changes

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DOX-induced mitochondrial toxicity on human cardiac AC16 cells. A, Representative confocal images

Figure 2

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Berberine stimulates calcium-induced depolarization. Freshly isolated mitochondria were energized with 5mM succinate/

K-means clustering analysis of in vitro assay endpoints. HL-60 cells were

Figure 4. Using MITO-ID® Membrane Potential dye was shown to decrease as a function of CCCP concentration (decrease in orange signal).

Schematic summary of the effects of THS on mitochondria and cell health. Short-term

S1 Fig. Identification of specific carbonylated proteins by 2D gel electrophoresis.

Figure 3. A) Acidification profiles of HepG2 cells illustrating the effect of compound drug treatment. B) Analysis of acidification rates allows the effect ...

Figure S1.

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mRNA Expression of PGC-1α and PGC-1α-regulated factors after denervation.

FIG. 2. Measured profiles of mitochondrial oxygen consumption: (A) Oxygen consumption measured by the conventional

Figure 2. Effect of allicin on H2O2-induced mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Osteoblasts were incubated with 10, 30 or 100 µg/ml ...

Nuclear translocation of Nrf2 during gastric mucosal injury by indomethacin. Nuclear fractions isolated from gastric

Figure 2: Effects of Cd on heme-oxygenase-1 expression. HepG2 cells

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Treatment and oligomycin OCR in HK-2. A, Average treatment-OCR relative

Figure 2. Effect of 100 µg/ml CP and 50 µM QR on GSH and NP-SH contents in rat liver mitochondria. QR attenuated the CP-induced decrease in (A) GSH and (B) ...

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Fig. 7. Cell death associated with multikinase inhibitors. (A) Induction of

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Fig. 1. Concepts of the endocrine-disrupting chemical (EDC)-induced

Figure 1. FIAU-induced liver toxicity develops in TK-NOG mice with humanized. Figure 2.

S1 Fig. Results of 5-dose screening of Cu(II) complex on NCI60 cell lines.

Oxygen consumption by isolated rat liver mitochondria was severely inhibited by nefazodone. (A)

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Figure 5. The mitochondria of HeLa cells were stained with MITO-ID® Membrane Potential reagent, and visualized by epifluorescence microscopy.

Figure 3. FIAU-induced liver toxicity is dose-dependent in TK- NOG

Figure 2. Adpa-manganese (Mn) induced apoptotic cell death via the mitochondrial pathway. (A) U251 cells were treated with Adpa-Mn (20 µM) for 24 h. The ...

S1 Fig. Histological characterization of proliferation in 3D liver tissues.

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S1 Fig. Echocardiographic data.

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Figure 2: Construction of plasmids used to establish Gluc or SEAP reporter gene assays for

Figure 8. Effects of POA on (A) MMP, (B) ATP and (C) MPTP in L-02 cells. Data are presented as the mean ± standard deviation. ***P <0.001. MMP, mitochondrial ...

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Fig. 1 Relationship between drug metabolism and toxicity. Toxicity may accrue through accumu-

Figure 9. Effect of POA on expression levels of cyt c in L-02 cells. β-actin served as an internal control. (A) Representative western blot images and (B) ...

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S1 Fig. The effect of paeonol on cytochrome P450 enzymes.

Fig. 9. Hypothetical mechanism of drug-induced PLDsis proposed by Sawada et al

Effect of Diclofenac (A), Fenofibrate (B), Flutamide (C)

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Fig. 5

Figure 4. Adpa-manganese (Mn) treatment induced mitochondrial dysfunction. ( A and B) U251 cells were exposed to Adpa-Mn (20 µM for 3, 6, 12 and 24 h; or 5, ...

Fig. 6. Protein expression of Opa1, Fis1 and LC3 in HepG2 cells.

Fig. 3 HO-1 attenuates Cd-induced oxidative stress. HepG2 cells were

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Fig. 3. Swelling of mitochondria isolated from SK-N-SH neuroblastoma cells

Table 2.

Figure 7

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Figure 2. Clinical Course of Patient 2, in Whom Hepatic Failure and Severe Lactic Acidosis Developed after Treatment with Fialuridine for Chronic Hepatitis ...

Figure S1.

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(B) The percentage of cell cycle phase was analyzed by flow cytometry analysis. (C) Activity of caspase 3 in L-02 cells after treatment with or without ...

S1 Fig. Sensitivity to ABT-199 and TW-37 in AML cell lines.

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a and b, Effect of overexpression of full-length Smac on TRAIL-, anti-CD95- or drug-induced apoptosis. SHEP neuroblastoma cells transfected with vector ...

Figure 5. Effect of oxalicumone A on protein expression levels of Fas, Bax and Bcl-2 in L-02 cells. β-actin served as internal control.

Figure 2. Effect of newer antiretroviral drugs on mitochondrial function and cellular viability in primary rat neurons.

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Fig. 8. Western blotting analysis of cytosolic JNK, cytosolic p-JNK, mitochondrial Bax, mitochondrial Bcl-2 and cytosolic p73 proteins in Hep3B cells ...

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