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Membrane vesicles as conveyors of immune responses t

Membrane vesicles as conveyors of immune responses t

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doi:10.1038/nri2567

Membrane vesicles as conveyors of immune responses

Antigen-independent roles in immune responses. In addition to MHC molecules, secreted membrane vesicles bear proteins that can inhibit or promote immune ...

In this mouse model, peptide--MHC class II complexes present on exosomes could participate in host DC recognition of alloantigen, but the outcome of this in ...

www.frontiersin.org. Table 1. Extracellular membrane vesicles ...

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EVs in the immune system: antigen presentation and acquired immunity. EVs may have a

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IJMS | Free Full-Text | Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

The role of exosomes in modulating the immune response: (A) tumour-derived

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Regulatory T ([T.sub.Reg]) cell

Regulation of immune responses by extracellular vesicles | Nature Reviews Immunology

Fig. 4. Activation of p53 by DNA damage induces the expression of TSAP6 which

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Experimental layout for in vivo analysis of immune responses to antigen-loaded extracellular vesicles. Exosomes and microvesicles from antigen-pulsed or ...

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

nteractions of exosomes and other nanoscale vesicles with cells of the immune system. A)

Fig. 3. Ubiquitin marks cargo proteins for endosomal sorting. Monoubiquitination appears to mark

Biogenesis of an outer membrane vesicle (OMV). Initialized by outward bulging of the

Clinical grade exosomes in immunotherapy. The process of how DeX can be derived, purified

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Regulation of immune responses by extracellular vesicles | Nature Reviews Immunology

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Different functions of immature and mature dendritic cells. A) In the absence of inflammation

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IJMS | Free Full-Text | Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System

Regulation of immune responses by extracellular vesicles | Nature Reviews Immunology

Dendritic cell-derived exosomes interact with T cells through MHC class

Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms

EVs from mesenchymal stem cells (MSC). EVs derived from MSCs can induce different

Graphical abstract

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The therapeutic application of AeX. Dendritic cells from peripheral blood monocytes are pulsed with AEX

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

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EVs in the tumour microenvironment | Philosophical Transactions of the Royal Society B: Biological Sciences

Interaction between cancer cells and BM-derived cells through extracellular vesicles (EVs).

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... 8. ...

OVA-loaded exosomes (Exo-OVA) but not microvesicles (MV-OVA) induce immune cell population changes in vivo. Exo-OVA, MV-OVA or a combination thereof was ...

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Figure 1

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The role of exosomes in modulating the immune response: (A) tumour-derived exosomes internalised by or fused with antigen-presenting cells (APCs) have been ...

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Alternative mechanisms how exosomes stimulate immune cells. (A) B cells might either recognize whole antigenic proteins on exosomes via their B cell ...

Regulation of immune responses by extracellular vesicles | Nature Reviews Immunology

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IJMS | Free Full-Text | Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing

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Graphical Abstract

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Using polystyrene-latex coated with anti-MHC class II antibodies, vesicles corresponding to the same total protein amounts ...

nteraction of engineered exosomes with cells of the immune system. A) engineered exosomes (

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ILVs, intraluminal vesicles; MVBs, multivesicular bodies.

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The biological function of TEXs in tumorigenesis.

MVs bud directly from the plasma membrane, whereas exosomes are represented by small vesicles of different sizes that are formed ...

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Extracellular vesicle (EV) internalization and miRNA transfer in human umbilical cord vein-derived endothelial cells (HUVECs). (A) Representative image of ...

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Extracellular vesicles: emerging targets for cancer therapy

Flow cytometric analysis of heterogeneous populations of cell-derived nanosized membrane vesicles.

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Biogenesis, composition, and function of extracellular vesicles

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SEB-loaded HaCaT cells induce the proliferation of resting CD3+ T cells in a non-contact assay. HaCaT cells and solute SEB (100 ng/ml) only served as ...