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Phase 2 Study of Hemoglobin Modifier GBT440 to Treat IPF Getting

Phase 2 Study of Hemoglobin Modifier GBT440 to Treat IPF Getting

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Phase 2 Study of Hemoglobin Modifier, GBT440, to Treat IPF Getting Underway

Phase 2 Study of Hemoglobin Modifier, GBT440, to Treat IPF Getting Underway

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Phase 2 Study of Hemoglobin Modifier, GBT440, to Treat IPF Getting Underway

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Hemoglobin Modifier GBT440 Being Tested for IPF Patients with Poor Blood Oxygen Levels .

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Global Blood Therapeutics GBT440 hemoglobin modifier for Sickle Cell Disease SCD

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We plan to conduct the Phase 3 HOPE Study at leading SCD sites around the globe, enrolling adults and adolescents with SCD who have had at least one episode ...

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Global Blood Therapeutics Announces Initiation of Phase 1 Trial to Evaluate the Physiologic Effects of GBT440 in Healthy Volunteers Under Hypoxemic ...

We reported initial results from our GBT440-001 Phase 1/2 clinical trial at the American Society of Hematology, or ASH, meeting in December 2015, ...

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... Inc. (GBT) (NASDAQ:GBT) today announced the discontinuation of its GBT440 program for the treatment of idiopathic pulmonary fibrosis (IPF).

... and anti-sickling activity provide evidence of inhibition of sickle hemoglobin polymerization, which may translate into improved symptoms, reduction in ...

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In various studies of SCD, scientists have demonstrated that hemoglobin in the oxygenated state is a potent inhibitor of HbS polymerization.

GBT440 for the Treatment of Sickle Cell Disease

GBT440 for the Treatment of Sickle Cell Disease

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In various studies of SCD, scientists have demonstrated that hemoglobin in the oxygenated state is a potent inhibitor of HbS polymerization.

Based on these results, we have initiated two Phase 2a clinical studies of GBT440 in IPF patients with hypoxemia: GBT440-006 and GBT440-026 (which we have ...

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Based on these results and subject to our filing and the clearance of an IND or CTA, we expect to initiate a Phase 2a clinical trial of GBT440 in a ...

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Phase 2 Study of Hemoglobin Modifier, GBT440, to Treat IPF Getting Underway | Idiopathic pulmonary fibrosis, Pulmonary fibrosis and Lungs

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... the company presented data from the 900 mg Part B portion of the HOPE-KIDS 1 Study for patients that had received 16 weeks of voxelotor treatment.

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The following figures present patient-by-patient data for the six SCD patients who received GBT440 and who have completed our once-daily, 28-day multidose ...

We also observed that GBT440 maintains HbS in its oxygenated state and delays the polymerization of deoxygenated HbS. Polymerization delay times predict the ...

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We are evaluating the safety, tolerability, pharmacokinetics, or PK, and pharmacodynamics, or PD, of GBT440, as well as exploratory markers of SCD activity, ...

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We believe the expanding clinical evidence demonstrating that GBT440 was well tolerated over 90 days of dosing and that GBT440 inhibits irreversibly sickled ...

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Phase 2 Study of Hemoglobin Modifier, GBT440, to Treat IPF Getting Underway | Idiopathic pulmonary fibrosis, Pulmonary fibrosis and Lungs

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